Erectile Dysfunction May Predict Development of Parkinson's Disease

01.10.2018

Erectile dysfunction is associated with a higher risk of developing Parkinson's disease

In a population-based retrospective cohort study were compared 3153 men newly diagnosed with Erectile Dysfunction with 12,612 randomly selected men without Erectile Dysfunction (controls). The incidence rate of Parkinson's disease was significantly higher in Erectile Dysfunction group than controls (3.44 vs 1.64 per 1000 person-years). The Erectile Dysfunction patients had a 52% higher risk of Parkinson's disease, after adjusting for age and comorbidities. Compared with controls, Erectile Dysfunction patients with diabetes or hypertension had a 2.8 times and 2.2 times higher risk of Parkinson's disease, respectively.

With respect to possible mechanisms to explain a link between Erectile Dysfunction and Parkinson's disease, we have to consider that Erectile Dysfunction as the manifestations of parasympathetic cholinergic failure, and the findings of previous studies suggest that many non-motor symptoms and autonomic dysfunction could early signs of preclinical stages of Parkinson's disease. Testosterone levels also might have a role. Lower testosterone levels, they noted, are an important component of Erectile Dysfunction, and previous studies have shown that testosterone deficiency is frequently found in men with Parkinson's disease compared with age-matched controls.

References

Yang Y, Liu H, Lin T, et al. Relationship between erectile dysfunction, comorbidity, and Parkinson's disease: Evidence from a population-based longitudinal study. J Clin Neurol2017;13:250-258).

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