Erectile Dysfunction Strongly Predicts Cardiovascular Events
Of 1914 participants (mean age 69 years) in MESA (Multi-Ethnic Study of Atherosclerosis), half (45.8%) reported ED symptoms. The group was 42% white, 24% black, 11% Chinese, and 23% Hispanic.
Over nearly 4 years of follow up, the cohort experienced 40 coronary heart disease (CHD) events and 74 cardiovascular (CVD) events. Significantly greater proportions of men with than without ED suffered an event: 3.4% vs 1.4% CHD events and 6.3% vs 2.6% CVD events. Men with ED had a 1.9 times greater risk for CVD events. Investigators adjusted for major risk factors such as smoking, diabetes, family history of CHD, cholesterol levels, and systolic blood pressure, as well as the use of lipid-lowering and antihypertensive medication, beta blockers, and even depression.
The results reveal that erectile dysfunction is, in and of itself, a potent predictor of cardiovascular risk. Moreover, the findings suggest that clinicians should perform further targeted screening in men with erectile dysfunction, regardless of other cardiac risk factors and should consider managing any other risk factors -- such as high blood pressure or cholesterol -- that much more aggressively.
Uddin SMI, Mirbolouk MH, Dardari Z, et al. Erectile Dysfunction as an independent predictor of future cardiovascular events: The Multi-Ethnic Study of Atherosclerosis. Circ. DOI: 10.1161/CIRCULATIONAHA.118.033990
Erectile dysfunction means increased risk for heart disease, regardless of other risk factors. Circulation Journal Report. American Heart Association; June 11, 2018. [news release]