Finasteride Cuts Prostate Cancer Risk Long Term
The finding extends the results of the Prostate Cancer Prevention Trial (PCPT), which demonstrated that 7 years of finasteride treatment decreased the risk of Prostate Cancer by 25% compared with placebo among men aged 55 years and older. Whether this risk-lowering effect of finasteride is maintained after discontinuing the drug has been unclear.
The beneficial effect was most pronounced in the first 7.5 years (29% reduction in Prostate Cancer risk), consistent with original PCPT findings, Dr Unger's team reported. After 7.5 years, the investigators observed no increased risk of PCa among finasteride recipients.
Unger JM, Hershman DL, Till C, et al. Using Medicare claims to examine long-term prostate cancer risk of finasteride in the Prostate Cancer Prevention Trial. J Natl Cancer Inst. 2018; DOI: 10.1093/jnci/djy035
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