Hyponatremia is a risk factor for kidney stones


Hyponatremia refers to a low level of sodium in the blood. Hyponatremia or low sodium blood levels may result from excess fluid in the body relative to a normal amount of sodium, or it may be due to a loss of sodium and body fluid caused by chronic conditions like kidney or congestive heart failure.

Kidney stones impose a large and increasing public health burden. Previous studies showed that hyponatremia is associated with an increased risk of osteoporosis and bone fractures, which are also known to be associated with kidney stones.  Chronic persistent hyponatremia is a significant and clinically important risk factor for kidney stones according recent study.


Tominaga N, Fernandez SJ, Mete M, et al. Hyponatremia and the risk of kidney stones: A matched case-control study in a large US health system. PLoS One. 2018;13(9):e0203942.