Ketones in the urine analysis

23.01.2018

Frequently happens in my daily practice to see patients with ketones in their urine analysis (Ketonuria). Most of the time an isolated Ketonuria does't really matter. Let'see some of the common causes.

Ketonuria occurs when fatty acids are moved from triglyceride stores in the body in response to inadequate intake or availability of carbohydrates. Under conditions of abnormal carbohydrate metabolism, such as occurs in diabetes mellitus, ketones accumulate in the blood (ketonemia) and are excreted in the urine (ketonuria). The accumulation of ketones is often the cause of acidosis and coma in diabetics. Ketonuria is also associated with:

  • Severe, sustained exercise
  • Starvation
  • Digestive disturbances
  • Dietary imbalance (high fat/low carbohydrate diet)
  • Fever
  • Prolonged vomiting and diarrhea
  • Eclampsia (a complication might happen during pregnancy)

Ketones are mildly toxic to the body, tending to interfere with the excretion of uric acid, produce mild depression of the central nervous system, and cause acidosis.

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