Kidney Damage Tied to Proton Pump Inhibitors


Individuals who take proton pump inhibitors (PPIs) are at increased risk of kidney damage. This relationship could have considerable public health impact; therefore, health care provider education and deprescribing initiatives will be necessary to raise awareness and reduce health care burden

Researchers found that patients who used PPIs had a significant 4-fold increased risk of acute kidney injury (AKI) and 1.2-fold increased risk of chronic kidney disease (CKD) compared with nonusers.

The study included 93,335 patients with AKI and 84,600 patients with CKD receiving care at a large population-based health maintenance organization. Of the patients in the AKI and CKD cohorts, 16,593 and 14,514 used PPIs, respectively. The incidence rate of AKI was significantly higher among PPI users than nonusers (36.4 vs 3.54 per 1000 person-years). The incidence rate of CKD was significantly higher among the PPI users than nonusers (34.3 vs 8.75 per 1000 person-years).


Hart E, Dunn TE, Feuerstein S, Jacobs DM. Proton pump inhibitors and risk of acute and chronic kidney disease: a retrospective cohort study. Pharmacotherapy. 2019; published online ahead of print.