Kidney stones and the risk of renal cancer
The Authors examined the association between kidney stones and renal cell carcinoma (RCC) and upper tract urothelial carcinoma (UTUC) risk in the Netherlands Cohort Study on diet and cancer.
In total, 120,852 participants aged 55-69 completed a self-administered questionnaire on diet, medical conditions and other risk factors for cancer at baseline (1986). After 20.3 years of cancer follow-up 4352 sub-cohort members, 544 RCC cases and 140 UTUC cases were eligible for case-cohort analysis.
Kidney stones were associated with an increased RCC risk (HR: 1.39, 95% CI 1.05-1.84), vs. no kidney stones. Kidney stones were associated with an increased risk of papillary RCC (HR: 3.08, 95% CI 1.55-6.11), but not clear-cell RCC (HR: 1.14, 95% CI 0.79-1.65). UTUC risk was increased for participants with kidney stones (HR: 1.66, 95% CI 1.03-2.68). An early kidney stone diagnosis (≤40 years) was associated with an increased RCC and UTUC risk, compared to later diagnosis.
Van de Pol JAA, van den Brandt PA, Schouten LJ. Kidney stones and risk of renal cell carcinoma and upper tract urothelial carcinoma: the Netherlands Cohort Study. Br J Cancer. 2018; published online ahead of print.