Lower Urinary Tract Infections (cystitis) More Likely to Resolve With Nitrofurantoin Than Fosfomycin
The guideline-recommended antibiotics were compared in a randomized controlled trial of 513 patients. Participants received either oral macrocrystalline nitrofurantoin (100 mg 3 times daily) for 5 days or a single 3 g dose of oral fosfomycin tromethamine.
At 28 days after treatment, 70% of nitrofurantoin recipients had complete resolution of symptoms compared with 58% of fosfomycin-treated patients. Moreover, 74% vs 63% of recipients, respectively, experienced microbiologic resolution, defined as eradication of the bacterial strain with no recurrence of bacteriuria.
Huttner A, Kowalczyk A, Turjeman A, et al. Effect of 5-Day Nitrofurantoin vs single-dose fosfomycin on clinical resolution of uncomplicated lower urinary tract infection in women: A randomized clinical trial. JAMA. doi:10.1001/jama.2018.3627 [Published online April 22, 2018.]