Metabolic Abnormalities Seen in Testicular Cancer Survivors


Testicular cancer survivors (TCS) have metabolic abnormalities characterized by hypertension and increased low-density lipoprotein (LDL) and total cholesterol, according to a study published in the Journal of the National Comprehensive Cancer Network.

Mohammad Abu Zaid, MD, from Indiana University in Indianapolis, and colleagues examined clinical and genetic metabolic syndrome (MetS) risk factors in 486 North American TCS aged <55 years at diagnosis and who received first-line chemotherapy.

Metabolic abnormalities in TCS are characterized by hypertension and increased LDL and total cholesterol levels but lower rates of decreased HDL levels and abdominal obesity, signifying possible shifts in fat distribution and fat metabolism.


Abu Zaid M, Gathirua-Mwangi WG, Fung C, et al. Clinical and Genetic Risk Factors for Adverse Metabolic Outcomes in North American Testicular Cancer Survivors. J Natl Compr Canc Netw 2018;16:257-265. doi: 10.6004/jnccn.2017.7046 

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