Metabolic Syndrome and Smoking, Up Nocturia Risk in BPH


Moderate or severe nocturia is more like to develop in men following transurethral resection of the prostate (TURP) for benign prostatic hyperplasia if they smoke or have metabolic syndrome (MetS)

For the study, 102 patients were prospectively enrolled before TURP (Trans-Urethral Resection of Prostate)

After TURP, 69% of men complained of 2 or more nocturia episodes nightly. Of the 39% with pre-existing MetS, 58% developed this degree of nocturia after TURP. Similarly, of the 61% of men who smoked, 52% had persistent moderate to severe nocturia after TURP. Both smoking and MetS were associated with significant 3-fold increased risk of moderate or severe nocturia.

Although these results should be confirmed, and the pathophysiology is yet to be completely understood, counselling smokers or patients with MetS about the risk of postoperative persistent nocturia is warranted according to our results.


De Nunzio C, Lombardo R, Tema G, et al. Metabolic syndrome and smoking are associated with persistence of nocturia after transurethral resection of prostate. Presented at the American Urological Association's 2018 annual meeting in San Francisco, May 18-21. Poster MP04-13.