Nocturia Associated With Oxidative Stress


Oxidative stress is essentially an imbalance between the production of free radicals and the ability of the body to counteract or detoxify their harmful effects through neutralization by antioxidants. Free radicals may react and damage DNA inducing chronic diseases and cancer.

Higher levels of an oxidative stress biomarker have been found in men and women with nocturia.

In an observational study, the authors examined several indicators of oxidative stress and their relationship with lower urinary tracts symptoms (LUTS) in 1113 men and women. They assessed LUTS using the International Prostate Symptom Score (IPSS) and Overactive Bladder Symptom Score (OABSS) questionnaires.

Advanced glycation end products (AGEs) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels were significantly higher in people with severe LUTS. Following multivariate logistic regression analyses, however, only AGEs were significantly associated with nocturia (more than 1 void nightly).

Whether rising levels of AGEs, measured by skin autofluorescence in the forearm, contribute to nocturia or vice versa remains an open question. Previous research has linked AGEs with diabetes, renal failure, vascular complications, and coronary heart disease, according to the study authors.

Considering that nocturia has been reported to be associated with several health-related disorders, our observation supports the negative effect of deteriorated general health status via oxidative stress on nocturia.


Matsumoto T, Hatakeyama S, Imai A, et al. The relationship between oxidative stress and lower urinary tract symptoms: Results from the community health survey in Japan. BJU Intl.DOI:10.1111/bju.14535. (Article manuscript published online Sept 14, 2018)