Nocturnal Polyuria Linked to Non-Dipping Blood Pressure


Researchers have found a relationship between nocturnal polyuria (NP) and blood pressure that rises or fails to fall at night.

Of 194 patients who experience 2 or more voids nightly, 67% had NP while reduced functional bladder capacity explained symptoms in only a minority overall (13%).

NP appeared less well treated. As nocturia episodes increased, the proportion of those with NP also increased. For example, all men complaining of 5 or more nocturia episodes nightly had NP. The investigators found no significant differences in age, lower urinary tract symptoms, or complications between those with and without NP.

A subset of 17 NP and 17 non-NP patients underwent ambulatory blood pressure monitoring. Significantly more men with NP had non-dipping blood pressure than men with other causes of nocturia (77% vs 41%). NP patients also were more likely to use 2 or more antihypertensive medications.

Non-dipping blood pressure might be a risk factor for NP, according to the team, although they could not prove a cause and effect relationship. The conclusion is that the treatment for non-dipping blood pressure may improve NP.


Takayama M, Omori S, Iwasaki K, et al. Relationship between nocturnal polyuria and non-dipping blood pressure in male patients with lower urinary tract symptoms. LUTS 2018:1-5. DOI: 10.1111/luts.12225