Overweight and obesity during adolescence increases the risk of renal cell carcinoma

25.03.2019

Overweight and obesity, compared with normal weight, in adolescence are associated with a 1.8- and 2.9-fold increased risk of renal cell carcinoma later in life, respectively,

While overweight among adults has been linked with renal cell carcinoma (RCC) risk, little is known about the potential influence of overweight and obesity during adolescence. To ascertain if the adolescent body mass index is associated with subsequent risk of RCC, it was identified a cohort of 238,788 Swedish men who underwent mandatory military conscription assessment between1969and1976at a mean age of18.5years. At the time of conscription assessment, physical and psychological tests were performed including measurements of height and weight. Participants were followed through linkage to the Swedish Cancer Registry to identify incident diagnoses of RCC. The association between body mass index (BMI, kg/m2)at conscription assessment and subsequent RCC was evaluated using multivariable Cox regression. During a follow-up of up to37years,266men were diagnosed with RCC. It was observed a trend for higher RCC risk with increasing BMI during adolescence, where the one-unit increase in BMI conferred a6% increased the risk of RCC (95%CI1.01-1.10). compared to normal weight men(BMI18.5-<25), men with overweight (BMI25-<30) or obesity (BMI≥30) had hazard ratios for RCC of1.76(95%CI1.16-2.67) and2.87(95%CI1.26-6.25), respectively. The link between overweight/obesity and RCC appear to be already established during late adolescence. Prevention of unhealthy weight gain during childhood and adolescence may thus be a target in efforts to decrease the burden of RCC in the adult population.

Reference

Landberg A, Fält A, Montgomery S, et al. Overweight and obesity during adolescence increase the risk of renal cell carcinoma. Int J Cancer. 2019; published online ahead of print.

https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.32147