Prostate Cancer Risk After Single Negative Biopsy


Almost one-quarter of men who have a single negative prostate biopsy are eventually diagnosed with prostate cancer (PCa) within 20 years

The 20-year cumulative rates of prostate cancer-specific mortality and diagnosis were 1.8% and 23.7%, respectively. Men ages 70 to 79 and 80 to 84 at initial biopsy had 20-year prostate cancer-specific mortality cumulative rates of 3.2% and 6.4% respectively. The 20-year cumulative rate of receiving radical prostatectomy was 7.6%. Higher socioeconomic status and urban residence were associated with higher diagnosis risks yet lower prostate cancer-specific mortality risks.

Following a negative initial biopsy, 23.7% of men are still diagnosed with and 1.8% die of prostate cancer within 20 years. Cancer-specific mortality outcomes are significantly worse in older men, with prostate cancer mortality rates several times higher than the rest of the population.


Sayyid RK, Alibhai SMH, Sutradhar R, et al. Population-based outcomes of men with a single negative prostate biopsy: Importance of continued follow-up among older adults. Urol Oncol. 2019; published online ahead of print.