Recurrent Cystitis Possibly Preventable by Drinking More Water
The study included 140 healthy women (mean age 35.7 years) with recurrent cystitis (3 or more episodes in the past year) who reported drinking less than 1.5 L of fluid daily. Investigators randomly assigned participants to drink 1.5 L of water daily in addition to their usual fluid intake (water group) or no additional fluids (control group) for 12 months. Each group had 70 participants.
During the 12-month study period, the mean number of cystitis episodes was 1.7 in the water group compared with 3.2 in the control group. The water group experienced 111 cystitis episodes, whereas the control group had 216 episodes.
In addition, the mean number of antimicrobial regimens used to treat cystitis episodes was 1.9 in the water group compared with 3.6 in the control group. The mean time interval between cystitis episodes was 142.8 days in the water group compared with 84.4 days in the control group. All of the between-group differences were statistically significant.
It seems appropriate for clinicians who counsel healthy women with recurrent cystitis to routinely ask about daily fluid intake and to recommend increased intake of water, especially in those who drink no more than 1.5 L of fluids daily, as a safe and inexpensive alternative to strategies that employ antimicrobials.
Hooton TM, Vecchio M, Iroz A, et al. Effect of increased daily water intake in premenopausal women with recurrent urinary tract infection. JAMA Intern Med. 2018; published online ahead of print.