Spermatogenesis Still Occurs in Men With Testicular Cancer
The Authors retrospectively reviewed 103 testicular germ cell tumours (TGCTs) in men who underwent radical orchidectomy (between 2011 and 2015) in order to assess the frequency and predictors of spermatogenesis.
The researchers found that spermatogenesis was present in 70% of the patients. Spermatogenesis was widespread in 63% of these patients and focal in 38%. Tumour type, stage, the presence of microcalcification, and tumour markers did not predict spermatogenesis. Spermatogenesis was 82% less likely among men with a percentage testis tumour occupation of >50% of their testis versus those with a percentage testis tumour occupation of <50%.
These findings can help predict and guide successful surgical sperm retrieval in testes with TGCTs. The finding of focal spermatogenesis in a third of patients would support a microsurgical approach to sperm retrieval at the time of orchidectomy to maximize success.
Moody JA, Ahmed K, Horsfield C, Pedersen MRV, Yap T, and Shabbir M. Fertility preservation in testicular cancer - predictors of spermatogenesis. BJU Int. DOI:10.1111/bju.14214 (Published online April 17, 2018)