Spot Urine Sodium-to-Potassium Ratio Predicts Stroke Risk


Higher spot urine sodium-to-potassium ratios are associated with increased stroke risk

Dietary sodium reduction with the concurrent increase in potassium intake is a current public health priority to reduce the risk of cardiovascular events. This study explored associations between the spot urine sodium-to-potassium ratio and cardiovascular events in the MESA (Multi-Ethnic Study of Atherosclerosis) longitudinal cohort.

The spot urine sodium-to-potassium ratio (measurable in routine care) is associated with stroke. A urine sodium-to-potassium ratio of ≤1, may be related to a clinically relevant reduction in stroke risk and is a feasible target for health interventions.


Averill MM, Young RL, Wood AC, et al. Spot urine sodium-to-potassium ratio is a predictor of stroke. Stroke. 2019;50:321-327.